Denic, Aleksandar; Bogojevic, Marija; Mullan, Aidan F.; Sabov, Moldovan; Asghar, Muhammad S.; Sethi, Sanjeev; Smith, Maxwell L.; Fervenza, Fernando C.; Glassock, Richard J.; Hommos, Musab S.; Rule, Andrew D. JASN October 2022, 33 (10) 1927-1941; DOI: https://doi.org/10.1681/ASN.2022030234 Chronic damage as assessed in the kidney biopsy is an independent predictor of renal function decline (doi: 10.1681/ASN.2017121260, doi: 10.1681/ASN.2021010044). Different grading systems for chronicity have been published: some are diagnosis-specific, […]
Category: Article Blog Post
used for posts about journal articles accompanied by a short blog
Discovery of autoantibodies targeting nephrin in minimal change disease supports a novel autoimmune etiology
Andrew J.B. Watts, Keith H. Keller, Gabriel Lerner, Ivy Rosales, A. Bernard Collins, Miroslav Sekulic, Sushrut S. Waikar, Anil Chandraker, Leonardo V. Riella, Mariam P. Alexander, Jonathan P. Troost, Junbo Chen, Damian Fermin, Jennifer L. Yee, Matthew G. Sampson, Laurence H. Beck, Joel M. Henderson, Anna Greka, Helmut G. Rennke and Astrid Weins. JASN January 2022, 33 (1) 238-252; DOI: https://doi.org/10.1681/ASN.2021060794 Blogged by Amélie Dendooven Minimal change disease (MCD) is a common diagnosis in children […]
Use of a smartphone camera for bedside evaluation of adequacy of kidney biopsies
Gurmukteshwar Singh, Mark Massak, Michael Czaplicki, Evan Young, Shree Sharma, Alex Chang, Ashok Bhanushali and Prince Anand. JASN September 2021, https://doi.org/10.1681/ASN.2021070898 Blogged by Amélie Dendooven Pathology diagnostics is dependent on adequate tissue sampling. Generally speaking, a kidney biopsy should contain at least 10 glomeruli for being considered representative. A large proportion of kidney biopsies now […]
De Novo and Relapsing Glomerular Diseases After COVID-19 Vaccination: What Do We Know So Far?
Andrew S Bomback, Satoru Kudose, Vivette D D’Agati. Am J Kidney Dis 2021, ScienceDirect or PubMed Blogged by Helmut Hopfer, August 12th, 2021 Vaccination is currently the central strategy to end the COVID-19 pandemic. Recently, cases describing new onset or flares of podocytopathies and glomerulonephritides after vaccination against SARS-CoV-2 have been reported and regulatory agencies are discussing […]
Immunofluorescence Staining for Immunoglobulin Heavy Chain/Light Chain on Kidney Biopsies is a Valuable Ancillary Technique For the Diagnosis of Monoclonal Gammopathy-Associated Kidney Diseases
blogged by Amélie Dendooven Samih H. Nasr, Mary E. Fidler, Samar M. Said, Justin W. Koepplin, Jamie M. Altamirano-Alonso, Nelson Leung. Kidney International. Published online: March 24, 2021. DOI:https://doi.org/10.1016/j.kint.2021.02.038 This recent article in KI describes the use of a new set of antibodies targeted against heavy-light Ig chain pairs for immunofluorescence on frozen sections. For […]
Renal ultrastructural findings and COVID-19
Blogged by Nicolas Kozakowski, March 1st, 2021 Unlike other pathologists, most nephropathologists are familiar with electron microscopy (EM). However, compared to some virologists, they are not specially trained in interpreting ultrastructural features connected to viral biology. A manifold of publications misinterpreting sub-cellular structures for coronavirus has arisen after the epidemic outbreak of COVID-19. Other […]
Consensus definitions for glomerular lesions by light and electron microscopy: recommendations from a working group of the Renal Pathology Society
Haas M, Seshan SV, Barisoni L, Amann K, Bajema I, Becker JU, Joh K, Ljubanovic D, Roberts ISD, Roelofs JJ, Sethi S, Zeng C, Jennette CJ. Kidney International 2020, https://doi.org/10.1016/j.kint.2020.08.006 Blogged by Amélie Dendooven, November 16th, 2020 In this paper, Mark Haas and colleagues present a comprehensive list of > 40 consensus definitions for light microscopy […]
Acute kidney injury pathology and pathophysiology: a retrospective review
By: Gaut JP, Liapis H: Acute kidney injury pathology and pathophysiology: a retrospective review. Clinical Kidney Journal 2020. https://doi.org/10.1093/ckj/sfaa142 Blogged by Nicolas Kozakowski, October 22nd, 2020 Joseph P Gaut and Helen Liapis present a detailed review article on the pathology of acute kidney injury (AKI), supported by excellent illustrations. The pathologist’s perspective on tubular and […]
Renal amyloidosis: validation of a proposed histological scoring system in an independent cohort
Hoelbeek JJ, Kers J, Steenbergen EJ, Roelofs JJTH, Florquin S. Clinical Kidney Journal 2020. https://doi.org/10.1093/ckj/sfaa019 Blogged by Nicolas Kozakowski, June 3rd, 2020 Hoelbeek et al evaluated in a retrospective Dutch multicentre study the value of an amyloid deposit burden score in kidney biopsies with the diagnosis of amyloidosis (of AL-type in 70 cases (75%), AA-type […]
Clinicopathological predictors of renal outcomes in light chain cast nephropathy: A multicenter retrospective study.
Royal V, Leung N, Troyanov S, … , Bridoux F, et al. Blood. 2020. doi: 10.1182/blood.2019003807. [Epub ahead of print]. Blogged by Amélie Dendooven, March 26, 2020 Current IMWG guidelines suggest renal biopsy is not necessary in a patient with high suspicion of light chain cast nephropathy (LCCN), namely AKI with high serum free light […]